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Isolated Limb Perfusions With Tumor Necrosis Factor and Melphalan for Locally Recurrent Soft Tissue Sarcoma in Previously Irradiated Limbs

✍ Scribed by T. E. Lans; D. J. Grünhagen; J. H. W. de Wilt; A. N. van Geel; A. M. M. Eggermont


Book ID
111771451
Publisher
Springer
Year
2005
Tongue
English
Weight
96 KB
Volume
12
Category
Article
ISSN
1068-9265

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## Background and Objectives: The prognosis for recurrent multifocal limb soft tissue sarcoma (STS) is dismal due to systemic spread. However, many of these patients undergo amputation due to ineffective local control. The purpose of the present study was to determine whether isolated limb perfusi

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## Abstract ## BACKGROUND Since 1992, isolated limb perfusion (ILP) with tumor necrosis factor‐α (TNFα) and melphalan has been used for the treatment of patients with unresectable soft tissue sarcomas of the extremities. The authors retrospectively studied the results of limb salvage surgery using