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Hyperthermic Isolated Limb Perfusion With Tumor Necrosis Factor-α and Melphalan in Advanced Soft-Tissue Sarcomas: Histopathological Considerations

✍ Scribed by Josephine Issakov; Ofer Merimsky; Mordechai Gutman; Yehuda Kollender; Dina Lev-Chelouche; Soubhi Abu-Abid; Beatriz Lifschitz-Mercer; Moshe Inbar; Joseph M. Klausner; Isaac Meller


Publisher
Springer
Year
2000
Tongue
English
Weight
657 KB
Volume
7
Category
Article
ISSN
1068-9265

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## Background and Objectives: The prognosis for recurrent multifocal limb soft tissue sarcoma (STS) is dismal due to systemic spread. However, many of these patients undergo amputation due to ineffective local control. The purpose of the present study was to determine whether isolated limb perfusi

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## Abstract ## BACKGROUND Since 1992, isolated limb perfusion (ILP) with tumor necrosis factor‐α (TNFα) and melphalan has been used for the treatment of patients with unresectable soft tissue sarcomas of the extremities. The authors retrospectively studied the results of limb salvage surgery using