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High dose tumor necrosis factor-α and melphalan administered via isolated limb perfusion for advanced limb soft tissue sarcoma results in a >90% response rate and limb preservation

✍ Scribed by Mordechai Gutman; Moshe Inbar; Dina Lev-Shlush; Subhi Abu-Abid; Martha Mozes; Samario Chaitchik; Itzhak Meller; Joseph M. Klausner

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
501 KB
Volume
79
Category
Article
ISSN
0008-543X

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✦ Synopsis

BACKGROUND.

Recombinant tumor necrosis factor-a (rTNF-a) is

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Multifocal soft tissue sarcoma: Limb salvage following hyperthermic isolated limb perfusion with high-dose tumor necrosis factor and melphalan
✍ Lev-Chelouche, Dina; Abu-Abeid, Subhi; Kollander, Yehuda; Meller, Isaac; Isakov, 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 61 KB 👁 2 views

## Background and Objectives: The prognosis for recurrent multifocal limb soft tissue sarcoma (STS) is dismal due to systemic spread. However, many of these patients undergo amputation due to ineffective local control. The purpose of the present study was to determine whether isolated limb perfusi

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Isolated limb perfusion with tumor necrosis factor-α and melphalan for patients with unresectable soft tissue sarcoma of the extremities
✍ Eva M. Noorda; Bart C. Vrouenraets; Omgo E. Nieweg; Frits van Coevorden; Gooike 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 90 KB

## Abstract ## BACKGROUND Since 1992, isolated limb perfusion (ILP) with tumor necrosis factor‐α (TNFα) and melphalan has been used for the treatment of patients with unresectable soft tissue sarcomas of the extremities. The authors retrospectively studied the results of limb salvage surgery using