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Is Volume of Distribution at Steady State a Meaningful Kinetic Variable?

✍ Scribed by GREENBLATT, DAVID J.; ABERNETHY, DARRELL R.; DIVOLL, MARCIA

Book ID
120812514
Publisher
Sage Publications
Year
1983
Tongue
English
Weight
1024 KB
Volume
23
Category
Article
ISSN
0091-2700

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The problem of finding the steady-state volume of distribution V ss for a linear pharmacokinetic system with peripheral drug elimination is considered. A commonly used equation V ss ΒΌ (D/AUC)\*MRT is applicable only for the systems with central (plasma) drug elimination. The following equation, V ss

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The volume of distribution at steady state is considered to be one of the primary pharmacokinetic measurements obtained from in vivo experiments. This quantity is quite commonly calculated using moments of the observed concentration curve, the process being referred to as noncompartmental analysis.