Determinant of the distribution volume at steady state for novel quinolone pazufloxacin in rats
β Scribed by Hiroyoshi Hayakawa; Kyoko Takagi; Yoko Fukushima Takano; Yasuhito Kawamura; Akira Tsuji
- Book ID
- 111769127
- Publisher
- Pharmaceutical Press
- Year
- 2002
- Tongue
- English
- Weight
- 221 KB
- Volume
- 54
- Category
- Article
- ISSN
- 2042-7158
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π SIMILAR VOLUMES
The assumption of an instant equilibrium between bound and unbound drug fractions is commonly applied in pharmacokinetic calculations. The equation for the calculation of the steady-state volume of distribution V ss from the time curve of drug concentration in plasma after intravenous bolus dose adm
The parameters characterizing tissue distribution refer to the tissue/plasma partition coefficients (Kp), which can be used to derive volume of distribution at steady-state (V(ss)). The effort for predicting drug distribution in human has been further expanded to calculation methods using in vitro-b