Results are reported on the regioselective C-deuteriation of a series of silyl enol ethers derived from aryl alkyl ketones using deuterium (D 2 ) gas as the deuterium source and palladium-on-barium sulfate as the mediator. These results highlight the numerous reaction pathways and different product
Investigations into the regioselective deuteriation of enolates derived from silyl enol ethers and enolacetates
✍ Scribed by Gregory S. Coumbarides; Jason Eames; Neluka Weerasooriya
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- French
- Weight
- 127 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0022-2135
- DOI
- 10.1002/jlcr.519
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✦ Synopsis
Abstract
Results are reported on the regioselective C‐deuteriation of a series of enolates derived from the addition of MeLi to the related enolacetate and silyl enol ether and discussed in terms of the similarity between these methods; comments are made on the possible role of the additive, lithium tert‐butoxide. Copyright © 2001 John Wiley & Sons, Ltd.
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