Results are reported on the regioselective C-deuteriation of a series of silyl enol ethers derived from aryl alkyl ketones using deuterium (D 2 ) gas as the deuterium source and palladium-on-barium sulfate as the mediator. These results highlight the numerous reaction pathways and different product
Investigations into the C-deuteriation of enol acetates derived from aryl alkyl ketones
✍ Scribed by Svitlana Buksha; Gregory S. Coumbarides; Marco Dingjan; Jason Eames; Michael J. Suggate; Neluka Weerasooriya
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- French
- Weight
- 176 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0022-2135
- DOI
- 10.1002/jlcr.928
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✦ Synopsis
Results are reported on the regioselective C-deuteriation of a series of enol acetates (derived from the aryl alkyl ketones) using molecular deuterium as the D-source and palladium-on-barium sulphate as the mediator. The results presented highlight potential problems associated with the deuteriation of enol acetates.
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Results are reported on the regioselective C-deuteriation of a series of enolates derived from the deprotonation of aryl alkyl ketones using dilithiated urea as the pro-base in the presence of a suitable deuterium donor.