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Inversion (11)(p15q22) with NUP98–DDX10 fusion gene in pediatric acute myeloid leukemia

✍ Scribed by Cristina Morerio; Maura Acquila; Annamaria Rapella; Elisa Tassano; Cristina Rosanda; Claudio Panarello

Book ID
113513004
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
261 KB
Volume
171
Category
Article
ISSN
0165-4608

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## Abstract The __NUP98__ gene at 11p15 is known to be fused to __DDX10, HOXA9, HOXA11, HOXA13, HOXD11, HOXD13, LEDGF__, __NSD1, NSD3, PMX1__, __RAP1GDS1__, and __TOP1__ in various hematologic malignancies. The common theme in all __NUP98__ chimeras is a transcript consisting of the 5′ part of __NU

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In a survey of childhood therapy-related acute myeloid leukemia/myelodysplastic syndrome (t-AML/MDS) in Japan, we found 11p15 translocations in 5 (6%) of 81 children with t-AML/MDS. t(11;17)(p15;q21), t(11;12)(p15;q13), t(7;11)(p15;p15), inv(11)(p15q22), and add(11)(p15) were each found in one patie