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A NUP98-positive acute myeloid leukemia with a t(11;12)(p15;q13) without HOXC cluster gene involvement

✍ Scribed by Roberta La Starza; Lucia Brandimarte; Valentina Pierini; Valeria Nofrini; Paolo Gorello; Barbara Crescenzi; Laura Berchicci; Caterina Matteucci; Silvia Romoli; Donatella Beacci; Roberto Rosati; Massimo F. Martelli; Cristina Mecucci

Book ID
113513565
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
98 KB
Volume
193
Category
Article
ISSN
0165-4608

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Fusion of the NUP98 gene and the homeobo
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## Abstract The __NUP98__ gene at 11p15 is known to be fused to __DDX10, HOXA9, HOXA11, HOXA13, HOXD11, HOXD13, LEDGF__, __NSD1, NSD3, PMX1__, __RAP1GDS1__, and __TOP1__ in various hematologic malignancies. The common theme in all __NUP98__ chimeras is a transcript consisting of the 5β€² part of __NU

Human homeobox gene HOXC13 is the partne
Human homeobox gene HOXC13 is the partner of NUP98 in adult acute myeloid leukemia with t(11;12)(p15;q13)
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## Abstract The chimeric gene __NUP98/HOXC13__ was detected in a patient with a de novo acute myeloid leukemia and a t(11;12)(p15;q13). Fluorescence in situ hybridization with PAC1173K1 identified the breakpoint on 11p15, indicating that the __NUP98__ gene was involved in the translocation. At 12q1