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A novel t(5;11)(q31;p15) involving the NUP98 gene on 11p15 is associated with a loss of the EGR1 gene on 5q31 in a patient with acute myeloid leukemia

✍ Scribed by Yong Wang; Yongquan Xue; Suning Chen; Yafang Wu; Jinlan Pan; Jun Zhang; Juan Shen


Book ID
113513708
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
410 KB
Volume
199
Category
Article
ISSN
0165-4608

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## Abstract The chimeric gene __NUP98/HOXC13__ was detected in a patient with a de novo acute myeloid leukemia and a t(11;12)(p15;q13). Fluorescence in situ hybridization with PAC1173K1 identified the breakpoint on 11p15, indicating that the __NUP98__ gene was involved in the translocation. At 12q1

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The nucleoporin gene NUP98 has been reported to be fused to 9 partner genes in hematologic malignancies with 11p15 translocations. The NUP98-HOXA9 fusion gene has been identified in acute myeloid leukemia (AML) and chronic myelogenous leukemia with t(7;11)(p15;p15). We report here a novel NUP98 part