Inverse Relationship between APC Gene Mutation in Gastric Adenomas and Development of Adenocarcinoma
β Scribed by Jae-Hyuk Lee; Susan C. Abraham; Hyun-Soo Kim; Jong-Hee Nam; Chan Choi; Min-Cheol Lee; Chang-Soo Park; Sang-Woo Juhng; Asif Rashid; Stanley R. Hamilton; Tsung-Teh Wu
- Book ID
- 117022090
- Publisher
- American Society for Investigative Pathology
- Year
- 2002
- Tongue
- English
- Weight
- 322 KB
- Volume
- 161
- Category
- Article
- ISSN
- 0002-9440
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Colorectal adenomas are macroscopically visible morphological changes of the mucosa that can develop focal carcinoma in the absence of surgical intervention. The successive molecular changes proposed to occur at different stages in the adenomacarcinoma sequence were primarily based on DNA studies of
In 584 consecutive patients with no previous history of cancer or polypectomy, 769 adenomas were excised endoscopically and classified retrospectively according to the following parameters: macroscopic growth pattern, size, histological type, grade of dysplasia, anatomical site, presence of adenocar