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Univariate and multivariate analyses of the relationship between adenocarcinoma and solitary and multiple adenomas in colorectal adenoma patients

✍ Scribed by B. Gatteschi; M. Costantini; P. Bruzzi; F. Merlo; R. Torcoli; G. Nicolo

Publisher: John Wiley and Sons
Year: 1991
Tongue: French
Weight: 447 KB
Volume: 49
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910490406

No coin nor oath required. For personal study only.

✦ Synopsis

In 584 consecutive patients with no previous history of cancer or polypectomy, 769 adenomas were excised endoscopically and classified retrospectively according to the following parameters: macroscopic growth pattern, size, histological type, grade of dysplasia, anatomical site, presence of adenocarcinoma (ADK), number of adenomas and sex and age of the patient. A multivariate logistic analysis confirmed that size and histological type are the 2 most important predictors of ADK, both in solitary and in multiple adenomas. Adenomas located in the sigmoid portion and in the rectum have an increased probability of ADK, independent of size and histology. Multiple polyps, when compared to solitary polyps, were more frequent in males (p < 0.01) and were more often larger than 2 cm. Significant similarities in histology, morphology and degree of dysplasia were observed among multiple adenomas from the same patient.

'To whom correspondence and reprint requests should be sent, at the Istituto Nazionale per la Ricerca sul Cancro, V.le Benedetto XVJO,

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