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Introduction of p21Waf1/Cip1 gene into a carcinoma cell line of the uterine cervix with inactivated p53

✍ Scribed by Yasuhiro Yokoyama; Yuichiro Takahashi; Shigeo Morishita; Midori Hashimoto; Teruhiko Tamaya

Book ID
117468516
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
157 KB
Volume
116
Category
Article
ISSN
0304-3835

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p21WAF1/Cip1 expression is associated wi
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p21 WAF1/Cip1 is a recently identified gene involved in cell cycle regulation through cyclin-CDK-complex inhibition. The expression of this gene in several cell lines seems to be induced by wild-type, but not mutant, p53. p21 WAF1/Cip1 expression has been studied at both mRNA and protein levels in a

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BACKGROUND. The clinical course of laryngeal squamous cell carcinoma (LSCC) varies considerably among patients. New biologic markers are needed to facilitate the stratification of individual patients within the conventional clinicopathologic stages of LSCC. METHODS. Eighty-three LSCCs from an equal