Expression of p21WAF1/CIP1 is unrelated to p53 tumour suppressor gene status in oral squamous cell carcinomas
β Scribed by J.I Yook; J Kim
- Book ID
- 114394223
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 468 KB
- Volume
- 34
- Category
- Article
- ISSN
- 1368-8375
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p21 WAF1/Cip1 is a recently identified gene involved in cell cycle regulation through cyclin-CDK-complex inhibition. The expression of this gene in several cell lines seems to be induced by wild-type, but not mutant, p53. p21 WAF1/Cip1 expression has been studied at both mRNA and protein levels in a
The growth-inhibitory protein p2I wAFI/cIpI is a potent inhibitor of various cyclin-dependent kinases, the expression of which is regulated at the transcriptional level by p53-dependent and -independent mechanisms. We examined p2 I wAFI/c'pI mRNA and protein expression in 5 human ovarian-adenocarcin