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p21Waf1/Cip1 Expression Is a Prognostic Marker in Curatively Resected Esophageal Squamous Cell Carcinoma, but Not p27Kip1, p53, or Rb

✍ Scribed by Marcelo E. Nita; Hirokazu Nagawa; Osamu Tominaga; Nelson Tsuno; Kenji Hatano; Joji Kitayama; Takashi Tsuruo; Carlos E. Domene; Tetsuichiro Muto


Publisher
Springer
Year
1999
Tongue
English
Weight
331 KB
Volume
6
Category
Article
ISSN
1068-9265

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p21WAF1/Cip1 expression is associated wi
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p21 WAF1/Cip1 is a recently identified gene involved in cell cycle regulation through cyclin-CDK-complex inhibition. The expression of this gene in several cell lines seems to be induced by wild-type, but not mutant, p53. p21 WAF1/Cip1 expression has been studied at both mRNA and protein levels in a

Expression of p21 (waf1/cip1/sdi1), but
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## RESULTS. Various levels of p21 and p53 immunoreactivities in carcinoma cells were detected in 30 (32%) and 60 (65%), respectively, of 93 samples. There was no 1 First Department of Pathology, Faculty of Medcorrelation between p21 and p53 expression. The 5-year survival rate of patients icine, T