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Interleukin-1β Induces Nuclear Factor κ B in Epithelial Cells Independently of the Production of Reactive Oxygen Intermediates

✍ Scribed by Giuseppina Bonizzi; Emmanuel Dejardin; Bernard Piret; Jacques Piette; Marie-Paule Merville; Vincent Bours


Book ID
115132140
Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
867 KB
Volume
242
Category
Article
ISSN
1432-1327

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## Abstract IL‐1β is an important mediator in the pathogenesis of type 1 diabetes both in vivo and in vitro and it has been shown to induce islet β‐cell apoptosis. Most of the IL‐1β effects seem to be mediated by NF‐κB transcription factor activation, but its role in the induction of islet β‐cell a