Pneumococcal Peptidoglycan-Polysaccharides Induce the Expression of Interleukin-8 in Airway Epithelial Cells by way of Nuclear Factor-κB, Nuclear Factor Interleukin-6, or Activation Protein-1 Dependent Mechanisms

CD40-CD40 ligand interactions in human m

CD40-CD40 ligand interactions in human microglia induce CXCL8 (interleukin-8) secretion by a mechanism dependent on activation of ERK1/2 and nuclear translocation of nuclear factor-κB (NFκB) and activator protein-1 (AP-1)

✍ Teresa G. D'Aversa; Eliseo A. Eugenin; Joan W. Berman 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 971 KB

## Abstract CXCL8 is a CXC chemokine that recruits leukocytes to sites of inflammation. Expression of CXCL8 in the CNS has been demonstrated in neuroinflammatory diseases, including human immunodeficiency virus (HIV‐1) encephalitis, but the mechanism of secretion of this chemokine is not fully unde