𝔖 Bobbio Scriptorium
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Interleukin-1β converting enzyme

✍ Scribed by REITER, LAWRENCE A. ;MARTIN, JOHN J.

Book ID
115099528
Publisher
Wiley (Blackwell Publishing)
Year
2009
Tongue
English
Weight
814 KB
Volume
41
Category
Article
ISSN
0367-8377

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Interleukin-1b converting enzyme (ICE) processes the inactive proIL-1b to the proinflammatory mature IL-1b. ICE belongs to a family of cysteine proteases that have been implicated in apoptosis. To address the biological functions of ICE, we generated ICE-deficient mice through gene targeting technol

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Interleukin-1b converting enzyme (ICE) is the first enzyme of a new family of cysteine endoproteinases to be isolated and characterized. An overview of the structure and activity of ICE is outlined together with highlights of salient features common to members of each of the family members.