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Interleukin-18 and interleukin-12 synergistically inhibit osteoclastic bone-resorbing activity

✍ Scribed by N. Yamada; S. Niwa; T. Tsujimura; T. Iwasaki; A. Sugihara; H. Futani; S. Hayashi; H. Okamura; H. Akedo; N. Terada

Book ID
117807635
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
188 KB
Volume
30
Category
Article
ISSN
8756-3282

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Interleukin-1 (IL-1) is one of the most potent boneresorbing factors involved in bone loss associated with inflammation. We previously reported that IL-1 prolonged the survival of multinucleated osteoclastlike cells (OCLs) formed in cocultures of murine osteoblasts/stromal cells and bone marrow cell