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Interleukin 1 Induces Multinucleation and Bone-Resorbing Activity of Osteoclasts in the Absence of Osteoblasts/Stromal Cells

✍ Scribed by Eijiro Jimi; Ichiro Nakamura; Le T. Duong; Tetsuro Ikebe; Naoyuki Takahashi; Gideon A. Rodan; Tatsuo Suda


Book ID
115603142
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
519 KB
Volume
247
Category
Article
ISSN
0014-4827

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Interleukin-1 (IL-1) is one of the most potent boneresorbing factors involved in bone loss associated with inflammation. We previously reported that IL-1 prolonged the survival of multinucleated osteoclastlike cells (OCLs) formed in cocultures of murine osteoblasts/stromal cells and bone marrow cell

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