NFKB activity is elevated in aging bone, uncouples osteoblasts and osteoclasts in vivo and mediates SIRT1 regulation of bone cells
✍ Scribed by J.R. Edwards⁎; L. Connelly; M. Moore; S. Lwin; F. Yull; J. Nyman; F. Elefteriou; G. Mundy
- Book ID
- 116322999
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 59 KB
- Volume
- 47
- Category
- Article
- ISSN
- 8756-3282
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## Abstract Receptor activator of nuclear factor kappa B ligand (RANKL), a potent regulator of osteoclast formation and function, is expressed by osteoblasts and bone marrow stromal cells. However, the molecular mechanism underlying RANKL expression in osteoblast/stromal cells remains largely uncle