Interleukin 1 production by a human acute monocytic leukemia cell line
β Scribed by Teresa Krakauer; Joost J. Oppenheim
- Book ID
- 113132588
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- English
- Weight
- 462 KB
- Volume
- 80
- Category
- Article
- ISSN
- 0008-8749
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## Abstract A human leukemic cell line (THPβ1) cultured from the blood of a boy with acute monocytic leukemia is described. This cell line had Fc and C3b receptors, but no surface or cytoplasmic immunoglobulins. HLA haplotypes of THPβ1 were HLAβA2, βA9, βB5, βDRW1 and βDRW2. The monocytic nature of
Human interleukin-1 (IL-l), free of contaminating lymphokines, was isolated from cultures of purified monoblasts from a patient with acute monocytic leukemia. Partially purified IL-1 (diafiltration, ultrafiltration, and isoelectric focusing) stimulated proliferation of subconfluent human fibroblasts