Interferons and indoleamine 2,3-dioxygenase: Role in antimicrobial and antitumor effects
✍ Scribed by J. M. Carlin; Y. Ozaki; G. I. Byrne; R. R. Brown; E. C. Borden
- Publisher
- Springer
- Year
- 1989
- Tongue
- English
- Weight
- 852 KB
- Volume
- 45
- Category
- Article
- ISSN
- 1420-682X
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## Abstract The first and rate‐limiting step of the kynurenine pathway, in which tryptophan (Trp) is converted to __N__‐formylkynurenine is catalyzed by two heme‐containing proteins, Indoleamine 2,3‐dioxygenase (IDO), and Tryptophan 2,3‐dioxygenase (TDO). In mammals, TDO is found exclusively in liv
Indoleamine 2,3-dioxygenase (IDO) is a tryptophan catabolizing enzyme that has a number of immunoregulatory effects. It is expressed at high levels in the gastrointestinal tract, particularly in the small intestine, and has been implicated in the control of intestinal inflammation. However, its prec
## Abstract Human indoleamine 2,3‐dioxygenase (hIDO), a monomeric heme enzyme, catalyzes the oxidative degradation of L‐tryptophan (L‐Trp) and other indoleamine derivatives. Its activity follows typical Michaelis–Menten behavior only for L‐Trp concentrations up to 50 μM; a further increase in the c