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Indoleamine 2,3-dioxygenase in intestinal immunity and inflammation

✍ Scribed by Bobby J. Cherayil

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
119 KB
Volume
15
Category
Article
ISSN
1078-0998

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✦ Synopsis

Indoleamine 2,3-dioxygenase (IDO) is a tryptophan catabolizing enzyme that has a number of immunoregulatory effects. It is expressed at high levels in the gastrointestinal tract, particularly in the small intestine, and has been implicated in the control of intestinal inflammation. However, its precise role in intestinal immunity is not well understood. This review will summarize the current state of knowledge about IDO function, particularly as it pertains to inflammatory responses in the gut.

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