## Abstract Following CD80/86 (B7) and TLR9 ligation, small subsets of splenic dendritic cells expressing CD19 (CD19^+^ DC) acquire potent T cell regulatory functions due to induced expression of the intracellular enzyme indoleamine 2,3‐dioxygenase (IDO), which catabolizes tryptophan. In CD19^+^ DC
Expression of interferon regulatory factors and indoleamine 2,3-dioxygenase inChlamydia trachomatis-infected synovial fibroblasts
✍ Scribed by J. Rödel; Annemarie Groh; Matthias Hartmann; Karl-Hermann Schmidt; Marc Lehmann; Wolfgang Lungershausen; Eberhard Straube
- Publisher
- Springer-Verlag
- Year
- 1999
- Tongue
- English
- Weight
- 169 KB
- Volume
- 187
- Category
- Article
- ISSN
- 0300-8584
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## Abstract Indoleamine 2,3‐dioxygenase (IDO), a tryptophan‐catabolizing enzyme, is an intracellular enzyme possessing various immunosuppressive properties. Here, we report the possible use of this enzyme to suppress proliferation of immune cells cocultured with IDO‐expressing fibroblasts of an all
Alterations in the rate of cellular tryptophan metabolism are involved in mediating important biological activities associated with cytokines and growth factors. Indoleamine 2,3-dioxygenase (IDO) and tryptophanyl-tRNA synthetase are enzymes of tryptophan metabolism whose expression in a variety of c