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Expression and prognosis role of indoleamine 2,3-dioxygenase in hepatocellular carcinoma

✍ Scribed by Ke Pan; Hui Wang; Min-shan Chen; Hua-kun Zhang; De-sheng Weng; Jun Zhou; Wei Huang; Jian-jun Li; Hai-feng Song; Jian-chuan Xia

Publisher: Springer-Verlag
Year: 2008
Tongue: English
Weight: 619 KB
Volume: 134
Category: Article
ISSN: 1432-1335
DOI: 10.1007/s00432-008-0395-1

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## Abstract Indoleamine 2,3‐dioxygenase (IDO), a tryptophan degrading enzyme, is a potent immunomodulatory factor. IDO expression in fibroblasts selectively induces apoptosis in immune cells but not in primary skin cells. However, the mechanism(s) of this selective effect of IDO‐induced low tryptop