Interactions in Model Vaccines Composed of Mixtures of Aluminum-Containing Adjuvants
โ Scribed by Ragheb H. Al-Shakhshir; Ann L. Lee; Joe L. White; Stanley L. Hem
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 408 KB
- Volume
- 169
- Category
- Article
- ISSN
- 0021-9797
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The effect of surfactants on protein adsorption has been The elutability of proteins from adjuvants in model vaccines recently reviewed by Arnebrant and Wahlgren (3). They composed of ovalbumin adsorbed by aluminum hydroxide adjuconcluded that surfactants may elute preadsorbed proteins vant or lysoz
The effect of adjusting the pH of a model ovalbumin (iep โซุโฌ 4.7) and aluminum hydroxide adjuvant (iep โซุโฌ 11.5) vaccine or a model lysozyme (iep โซุโฌ 11.4) and aluminum phosphate adjuvant (iep โซุโฌ 5.0) vaccine to values ranging from 3 to 11 was studied. The model vaccine prepared at pH 7.4 served as
The mechanism(s) of the enhancement of the immune response by addition of aluminum salt adjuvants to parenterally administered protein-based vaccines is still the subject of debate. It has been hypothesized, however, that destabilization of the antigen structure on the surface of the adjuvant may be