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Interaction of trans-diamminedichloroplatinum(II) with DNA: formation of monofunctional adducts and their reaction with glutathione

✍ Scribed by Eastman, Alan; Barry, Michael A.

Book ID
111984475
Publisher
American Chemical Society
Year
1987
Tongue
English
Weight
570 KB
Volume
26
Category
Article
ISSN
0006-2960

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## Abstract The interactions of the ribonucleotide poly C with __cis__‐ and __trans__‐diamminedichloroplatinum (II) were probed with Raman spectroscopy. Both platinum compounds attack the __N__‐1 position of the cytosine residue, while the __trans__ form appears to attack the PO~2~^βˆ’^ as well. Rama