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Interaction of poly(I)·poly(C) with trans-dichloro-diammine-platinum (II)

✍ Scribed by Dominique Hermann; G. Victor Fazakerley; Claude Houssier; Wilhelm Guschlbauer

Publisher
Wiley (John Wiley & Sons)
Year
1984
Tongue
English
Weight
737 KB
Volume
23
Category
Article
ISSN
0006-3525

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✦ Synopsis

The covalent binding of trans -Pt (NH&C12 to the double-stranded poly(lbpoIy(C) follows three types of reactions, depending on rb and the concentration of polynucleotide in the reaction mixture. At i-b 5 0.1, the principal reaction is coordination to poly(I), giving rise to some destabilization of the double strand, as shown by uv and CD spectra, and a decrease in r, values, giving rise to free loops of poly(C). At higher rb and low polynucleotide concentration, the free cytidine bases react with platinum hound on the complementary strand to form intramolecular (interstrand) crosslinks that restabilize the double-stranded structure. At high rb and high polynucleotide concentration, while the above reaction still occurs, the predominant one is the formation of intermolecular crosslinks. Under no conditions has strand separation been observed.

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