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Proton NMR study of the interaction of cis-dichloro-diamine-platinum(II) with poly(I) and poly(I)·poly(C)

✍ Scribed by G. Victor Fazakerley; Dominique Hermann; Wilhelm Guschlbauer

Publisher
Wiley (John Wiley & Sons)
Year
1980
Tongue
English
Weight
557 KB
Volume
19
Category
Article
ISSN
0006-3525

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✦ Synopsis

The fixation of cis(NH&C12Pt(II) to poly(1)-poly(C) leads to the formation of two complexed species. One involves coordination to a single base (accounting for about 70% of the total platinum bound over the Fb range 0.07-0.25) and the other to two bases which are not adjacent to each other but may be on the same strand and separated by a loop. Reaction of the platinum compound with poly(1) gives in addition to the above two species a minor one (about 15%, independent of Fb over the range 0.05-0.30) in which the platinum is bound to two adjacent bases. The availability of such coordination reduces the dominance of the 1:l species, which, however, remains the major one (ca. 55%).

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