Interaction of benzo[a]pyrene diol-epoxide with nuclei and isolated chromatin
✍ Scribed by A. Kootstra; T.J. Slaga; D.E. Olins
- Book ID
- 113136103
- Publisher
- Elsevier Science
- Year
- 1979
- Tongue
- English
- Weight
- 720 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0009-2797
No coin nor oath required. For personal study only.
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## Abstract The frequency of cell transformation was determined after treatment of normal hamster embryo cells with benzo(a)pyrene (BP) and six of its metabolites. These metabolites included the __trans__ 4,5‐, 7,8‐ and 9,10‐dihydrodiols; the 4,5‐epoxide; and two stereoisomers of the non‐K‐region d
## Abstract Treatment of isolated rat liver nuclei with 7β, 8α‐dihydroxy‐9α, 10α‐epoxy‐7, 8, 9, 10‐tetrahy‐drobenzo[a]pyrene, the ultimate carcinogenic metabolite of benzo[a]pyrene, resulted in inhibition of transcription as measured by radioactive precursor incorporation into RNA. The mechanism of