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High mutagenicity and toxicity of a diol epoxide derived from benzo[a]pyrene

✍ Scribed by P.G. Wislocki; A.W. Wood; R.L. Chang; W. Levin; H. Yagi; O. Hernandez; D.M. Jerina; A.H. Conney

Book ID: 118311288
Publisher: Elsevier Science
Year: 1976
Tongue: English
Weight: 413 KB
Volume: 68
Category: Article
ISSN: 0006-291X
DOI: 10.1016/0006-291x(76)91246-8

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## Abstract The frequency of cell transformation was determined after treatment of normal hamster embryo cells with benzo(a)pyrene (BP) and six of its metabolites. These metabolites included the __trans__ 4,5‐, 7,8‐ and 9,10‐dihydrodiols; the 4,5‐epoxide; and two stereoisomers of the non‐K‐region d