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Exceptional mutagenicity of a benzo[a]pyrene diol epoxide in cultured mammalian cells

✍ Scribed by NEWBOLD, ROBERT F.; BROOKES, PETER

Book ID
109699136
Publisher
Nature Publishing Group
Year
1976
Tongue
English
Weight
349 KB
Volume
261
Category
Article
ISSN
0028-0836

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## Abstract The frequency of cell transformation was determined after treatment of normal hamster embryo cells with benzo(a)pyrene (BP) and six of its metabolites. These metabolites included the __trans__ 4,5‐, 7,8‐ and 9,10‐dihydrodiols; the 4,5‐epoxide; and two stereoisomers of the non‐K‐region d