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Stabilization of a reactive, electophilic carcinogen, benzo[a]pyrene diol epoxide, by mammalian cells

✍ Scribed by Michael C. Macleod; Gerald Adair; Dawn Dickson-Black; Tomas Pevny; Ronald M. Humphrey


Book ID
113137012
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
588 KB
Volume
63
Category
Article
ISSN
0009-2797

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## Abstract The frequency of cell transformation was determined after treatment of normal hamster embryo cells with benzo(a)pyrene (BP) and six of its metabolites. These metabolites included the __trans__ 4,5‐, 7,8‐ and 9,10‐dihydrodiols; the 4,5‐epoxide; and two stereoisomers of the non‐K‐region d