Intensive chemotherapy(CT) after remission induction with all-trans-retinoic acid (ATRA) in acute promyelocytic leukemia (APL)
✍ Scribed by Sousa, AB; Femandes, JP; Mesquita, V; Ferreira, G; Ribeiro, P; Bernardo, M; Nunes, O; Aveiro, F; Cruz, E; Veiga, J; Neves, A; Conduto, A; Rodrigues, AS; Monteiro, A; Soares, VH; Pereira, AM; Sousa, M; Gonçaives, AJ; Costa, I; Machado, M; Gouveia, J
- Book ID
- 121980161
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 162 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0959-8049
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Acute promyelocytic leukemia is characterized by the reciprocal translocation of chromosomes 15 and 17. All-trans retinoic acid (ATRA) efficiently induces differentiation of the abnormal promyelocytes. In this study, we had used ATRA as the primary induction therapy for 17 newly diagnosed patients,
This study was conducted to compare the results of treatment of acute promyelocytic leukemia (APL) with all-trans retinoic acid alone (ATRA) or a combination therapy of ATRA followed by chemotherapy. Forty-three patients treated between February 1992 and February 1996 were included in this study. Ei