All-trans retinoic acid therapy for newly diagnosed acute promyelocytic leukemia: comparison with intensive chemotherapy
β Scribed by N. Asou; Koichi Adachi; Jun-ichi Tamura; Akihisa Kanamaru; Shin-ichi Kageyama; Akira Hiraoka; Eijiro Omoto; Hisashi Sakamaki; Kazuo Tsubaki; Kenji Saito; Ryuzo Ohno
- Publisher
- Springer
- Year
- 1997
- Tongue
- English
- Weight
- 130 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0344-5704
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Background. Differentiation therapy with all-trans retinoic acid (RA) induces more than 80% complete remission with the least complications in patients with acute promyelocytic leukemia (APL). The authors studied the cost-benefit of this new treatment modality compared with conventional chemotherapy
This study was conducted to compare the results of treatment of acute promyelocytic leukemia (APL) with all-trans retinoic acid alone (ATRA) or a combination therapy of ATRA followed by chemotherapy. Forty-three patients treated between February 1992 and February 1996 were included in this study. Ei
Background. All-trans retinoic acid (ATRA) is effective in the treatment of relapsed or refractory acute promyelocytic leukemia (APL), but relapse is the rule if response is unmaintained. Methods. Seventeen patients with APL were salvaged with ATRA at a dosage of 50 mg/mz/day for 3 months or until