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Insulin-like growth factor-binding protein-5 (IGFBP-5) inhibits TNF-α-induced NF-κB activity by binding to TNFR1

✍ Scribed by Jae Ryoung Hwang; Jae Ho Huh; Yoonna Lee; Sang Il Lee; Seung Bae Rho; Je-Ho Lee


Book ID
116301353
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
817 KB
Volume
405
Category
Article
ISSN
0006-291X

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## Abstract Insulin‐like growth factor binding protein‐5 (IGFBP‐5) and thrombospondin‐1 (TS‐1) are both present in extracellular matrix (ECM). Both proteins have been shown to bind to one another with high affinity. The purpose of these studies was to determine how the interaction between IGFBP‐5 a