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Pregnancy-associated plasma protein-A (PAPP-A) cleaves insulin-like growth factor binding protein (IGFBP)-5 independent of IGF: implications for the mechanism of IGFBP-4 proteolysis by PAPP-A

✍ Scribed by Lisbeth S. Laursen; Michael T. Overgaard; Rikke Søe; Henning B. Boldt; Lars Sottrup-Jensen; Linda C. Giudice; Cheryl A. Conover; Claus Oxvig


Book ID
117103295
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
413 KB
Volume
504
Category
Article
ISSN
0014-5793

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We have previously shown that the insulin-like growth factors (IGFs) stimulate both proliferation and differentiation of skeletal muscle cells in culture, and that these actions in L6A1 muscle cells may be modulated by three secreted IGF binding proteins (IGFBPs), IGFBP-4, -5, and -6. Since we found