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IGF dependent modulation of IGF binding protein (IGFBP) proteolysis by pregnancy-associated plasma protein-A (PAPP-A): Multiple PAPP-A–IGFBP interaction sites

✍ Scribed by Gaidamauskas, Ervinas; Gyrup, Claus; Boldt, Henning B.; Schack, Vivien R.; Overgaard, Michael T.; Laursen, Lisbeth S.; Oxvig, Claus

Book ID: 118038691
Publisher: Elsevier Science
Year: 2013
Tongue: English
Weight: 579 KB
Volume: 1830
Category: Article
ISSN: 0304-4165
DOI: 10.1016/j.bbagen.2012.11.002

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## Abstract A Kunitz‐type protease inhibitor, bikunin, downregulates expression of uPA and its receptor uPAR at the mRNA and protein levels in several types of tumor cells. Our recent work showed that, using a cDNA microarray analysis, pregnancy‐associated plasma protein‐A (PAPP‐A) is a candidate b