Retinoic Acid Inhibits Cell Growth in HPV Negative Cervical Carcinoma Cells by Induction of Insulin-like Growth Factor Binding Protein-5 (IGFBP-5) Secretion
β Scribed by Hiromi Higo; Cunming Duan; David R. Clemmons; Brian Herman
- Book ID
- 115581038
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 174 KB
- Volume
- 239
- Category
- Article
- ISSN
- 0006-291X
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We observed that all-trans-retinoic acid (RA) down-regulated insulin-like growth factor binding proteins (IGFBPs) in cultured human hepatoma cells (Hep 3B, PLC/PRF/5, and Hep G2); therefore, we characterized the role of this down-regulation in cell growth. Treatment with 10 micromol/L RA revealed a
## Abstract The present study examined the effects of allβ__trans__ retinoic acid (tRA) on proliferation and expression of the IGF system in Cacoβ2 human colon adenocarcinoma cells. tRA inhibited Cacoβ2 cell proliferation in a doseβdependent manner, with a 40βΒ±β2% decrease in cell number observed 4