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Differential regulation of insulin-like growth factor binding protein (IGFBP)-2 mRNA in liver and bone cells by insulin and retinoic acid in vitro

✍ Scribed by Ch. Schmid; I. Schla¨pfer; M. Waldvogel; P.J. Meier; J. Schwander; M. Bo¨ni-Schnetzler; J. Zapf; E.R. Froesch


Book ID
115926209
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
514 KB
Volume
303
Category
Article
ISSN
0014-5793

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We observed that all-trans-retinoic acid (RA) down-regulated insulin-like growth factor binding proteins (IGFBPs) in cultured human hepatoma cells (Hep 3B, PLC/PRF/5, and Hep G2); therefore, we characterized the role of this down-regulation in cell growth. Treatment with 10 micromol/L RA revealed a