We have previously shown that the insulin-like growth factors (IGFs) stimulate both proliferation and differentiation of skeletal muscle cells in culture, and that these actions in L6A1 muscle cells may be modulated by three secreted IGF binding proteins (IGFBPs), IGFBP-4, -5, and -6. Since we found
Induced secretion of insulin-like growth factor binding protein-1 (IGFBP-1) in human hepatoma cell HepG2 by rubratoxin B
โ Scribed by Hitoshi Nagashima; Kumiko Maeda-Nakamura; Keiko Iwashita; Tetsuhisa Goto
- Publisher
- Springer-Verlag
- Year
- 2006
- Tongue
- English
- Weight
- 303 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0340-5761
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Insulin-like growth factor-I (IGF-I) is essential for normal epidermal homeostasis; however, the role of IGF binding proteins (IGFBPs), regulators of IGF action, remains unclear. Here we examine the regulation of human keratinocyte-produced IGFBPs by epidermal growth factor (EGF), transforming growt
A sensitive RIA was used to examine regulation of IGFBP-1 in H411E rat hepatoma cells. IGFBP-1 was stimulated up to tenfold by dexamethasone and corticosterone, and this stimulation was abolished by RU486. The effect of dexamethasone increased with time in culture. Phorbol 12-myristate 13-acetate (P
Osteogenic protein-1 (OP-1 or BMP-7) stimulates new bone formation in vivo and induces cell proliferation and differentiation of osteoblasts in vitro. Previous studies from our laboratory revealed that OP-1 led to a two-to threefold increase in steady-state insulin-like growth factor-I (IGF-I) and I