✦ LIBER ✦

Innovative approaches to gene therapy

✍ Scribed by Vincent Cunliffe; David Thatcher; Roger Craig

Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 424 KB
Volume: 6
Category: Article
ISSN: 0958-1669
DOI: 10.1016/0958-1669(95)80116-2

No coin nor oath required. For personal study only.

✦ Synopsis

The past year has witnessed several advances in the development of targeted, cell-specific gene delivery systems of both viral and non-viral origin. Progress has been made in understanding the cellular mechanisms of nuclear import, and novel sequence-specific integrases have been developed that mediate insertion of DNA molecules into specific target sequences. Knowledge of the mechanisms by which herpes simplex virus and Epstein-Barr virus escape from immune surveillance has also advanced significantly; this may be exploited to reduce the immunogenicity of certain therapeutic gene products.

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