๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Non-viral approaches to gene therapy

โœ Scribed by Matt Cotten; Ernst Wagner

Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
516 KB
Volume
4
Category
Article
ISSN
0958-1669

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โœฆ Synopsis

Several advances in non-viral gene transfer technology have been reported over the past year. Cationic lipids have been successfully used to deliver genes in vivo, providing a clear alternative to recombinant viruses. In addition, investigators have demonstrated that direct application of DNA via injection or particle bombardment can be used for vaccination. Analysis of the mechanisms employed by viruses to invade cells has demonstrated a crucial role for membrane-active proteins or peptides in the entry process. Several non-viral systems that include membrane-active elements are now available.

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