New approaches to drug discovery have come about in recent years as a result of important advances in genomics and bioinformatics. The availability of genome-scale sequence data, the development of new tools for highthroughput gene expression monitoring, and improvements in the ability to analyze la
Innovative approaches to novel antibacterial drug discovery
β Scribed by Joaquim Trias; Eric M Gordon
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 603 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0958-1669
No coin nor oath required. For personal study only.
β¦ Synopsis
Increasing antibiotic resistance in microorganisms and new emerging pathogens have become a major problem in our society. Rising to satisfy this urgent medical need is a recent confluence of powerful new drug discovery technologies: combinatorial chemistry; sequence and functional genomic analysis; and novel methods of high-throughput screening. The combination of these technologies will bring to bear untapped power in the search for new antimicrobials.
π SIMILAR VOLUMES
With the completion of numerous bacterial genome sequences, the discovery of antibacterial drugs has fully entered the genomic era. The strategies for effectively using genomic information for target identification, target characterization, screen development and compound evaluation are emerging, an