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The Synthesis of Novel Heterocyclics as one Approach to Drug Discovery

✍ Scribed by Robert Westwood

Publisher
Wiley (John Wiley & Sons)
Year
2010
Weight
105 KB
Volume
90
Category
Article
ISSN
0037-9646

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Hetero-Diels-Alder reaction of the steroidal exocyclic enol ethers 14 and 15, obtained from the secoestrones 8 and 9 by reduction, iodoetherification, and elimination, with ethyl O-benzoyldiformylacetate (16) leads to the spiroacetals 17 and 18 as a mixture of four diastereomers. Reduction of the ma