Inhibitory Effects of Diallyl Bisulfide or Aspirin on 2-Amino-l-methyl-6-phenylimidazo[4,5-b]pyridine-induced Mammary Carcinogenesis in Rats
β Scribed by Suzui, Natsuko ;Sugie, Shigeyuki ;Rahman, K. M. Wahidur ;Ohnishi, Masami ;Yoshimi, Naoki ;Wakabayashi, Keiji ;Mori, Hideki
- Book ID
- 108581467
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 1997
- Tongue
- English
- Weight
- 394 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0910-5050
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP), a compound found in cooked meat, is a mammary gland carcinogen in female Sprague-Dawley rats. PhIP-induced rat mammary gland carcinomas were examined for mutations in several genes (exons) known to regulate cell growth and apoptosis, including
## Abstract Reduced expression of BRCA1 protein, caused by the hypermethylation of its gene promoter and by other mechanisms, is observed in most sporadic human breast cancers, whereas its somatic mutations are rare. In the present study, we demonstrate that immunoreactivity of __Brca1__ was reduce