✦ LIBER ✦

Studies on mammary carcinogenesis induced by a heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, in mice and rats

✍ Scribed by Minako Nagao; Toshikazu Ushijima; Naoko Watanabe; Eriko Okochi; Masako Ochiai; Hitoshi Nakagama; Takashi Sugimura

Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 87 KB
Volume: 39
Category: Article
ISSN: 0893-6692
DOI: 10.1002/em.10047

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Mammary gland carcinogenesis by food-der

Mammary gland carcinogenesis by food-derived heterocyclic amines: Metabolism and additional factors influencing carcinogenesis by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)

✍ Elizabeth G. Snyderwine 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 90 KB

## Abstract The heterocyclic amines (HCAs) are a family of mutagenic/carcinogenic compounds found in cooked meats. Several HCAs are mammary gland carcinogens in rats. Of these compounds, 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐__b__]pyridine (PhIP) is the major one present in the human diet. This repo

Genomic imbalance in rat mammary gland c

Genomic imbalance in rat mammary gland carcinomas induced by 2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine

✍ Minshu Yu; Doug-Young Ryu; Elizabeth G. Snyderwine 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 149 KB

2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP), a compound found in cooked meat, is a mammary gland carcinogen in female Sprague-Dawley rats. PhIP-induced rat mammary gland carcinomas were examined for mutations in several genes (exons) known to regulate cell growth and apoptosis, including

Reduced Brca1 protein expression in 2-am

Reduced Brca1 protein expression in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine–induced rat mammary carcinomas

✍ Eriko Okochi; Kazuaki Miyamoto; Kuniko Wakazono; Hiroshi Shima; Takashi Sugimura 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 236 KB

## Abstract Reduced expression of BRCA1 protein, caused by the hypermethylation of its gene promoter and by other mechanisms, is observed in most sporadic human breast cancers, whereas its somatic mutations are rare. In the present study, we demonstrate that immunoreactivity of __Brca1__ was reduce

Microsatellite instability and loss of h

Microsatellite instability and loss of heterozygosity on chromosome 10 in rat mammary tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

✍ Minoru Toyota; Toshikazu Ushijima; John H. Weisburger; Yoko Hosoya; Federico Can 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 596 KB

## Microsatellite instability (MI) and loss of heterozygosity (LOH) were examined in mammary tumors induced in Sprague-Dawley x F344 F1 female rats by 2-amino-l-methyl-6-phenylimidazo[4,5-blpyridine (PhlP). Examination of 62 microsatellite loci revealed M I in nine of 15 (60%) PhlP-induced mammary

2-Amino-1-methyl-6-phenylimidazo[4,5-b]p

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)–induced mutagenesis in cultured Big Blue™ rat mammary epithelial and fibroblast cells

✍ Heather M. McDiarmid; George R. Douglas; Brenda L. Coomber; P. David Josephy 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 184 KB

## Abstract Epithelial cells are the primary site of carcinogenesis in most tissues, including the mammary gland. As an alternative to the study of mutation induction in whole tissues in vivo, we have established Big Blue™ transgenic rat cell lines from the mammary epithelium (BBR/ME) and the mamma

Effects of 2-amino-1-methyl-6-phenylimid

Effects of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine on intestinal polyp development in ApcΔ716 knockout mice

✍ Masanobu Oshima; Hiroko Oshima; Masahiro Tsutsumi; Susumu Nishimura; Takashi Sug 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 655 KB

Damage to the human adenomatous polyposis coli (APC) gene is responsible for not only familial adenomatous polyposis but also many sporadic cancers of the entire digestive tract. Using homologous recombination in embryonic stem cells, we recently constructed gene knockout mice with a truncation muta