𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Dose-dependent Induction of Mammary Carcinomas in Female Sprague-Dawley Rats with 2-Amino-l-methyl-6-phenylimidazo[4,5-b]pyridine

✍ Scribed by Imaida, Katsumi ;Hagiwara, Akihiro ;Yada, Hideaki ;Masui, Tsuneo ;Hasegawa, Ryohei ;Hirose, Masao ;Sugimura, Takashi ;Ito, Nobuyuki ;Shirai, Tomoyuki

Book ID
108581289
Publisher
Wiley (Blackwell Publishing)
Year
1996
Tongue
English
Weight
268 KB
Volume
87
Category
Article
ISSN
0910-5050

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

Genomic imbalance in rat mammary gland c
Genomic imbalance in rat mammary gland carcinomas induced by 2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
✍ Minshu Yu; Doug-Young Ryu; Elizabeth G. Snyderwine πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 149 KB

2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP), a compound found in cooked meat, is a mammary gland carcinogen in female Sprague-Dawley rats. PhIP-induced rat mammary gland carcinomas were examined for mutations in several genes (exons) known to regulate cell growth and apoptosis, including

Reduced Brca1 protein expression in 2-am
Reduced Brca1 protein expression in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine–induced rat mammary carcinomas
✍ Eriko Okochi; Kazuaki Miyamoto; Kuniko Wakazono; Hiroshi Shima; Takashi Sugimura πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 236 KB

## Abstract Reduced expression of BRCA1 protein, caused by the hypermethylation of its gene promoter and by other mechanisms, is observed in most sporadic human breast cancers, whereas its somatic mutations are rare. In the present study, we demonstrate that immunoreactivity of __Brca1__ was reduce