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Inhibitors of HSP90 and other chaperones for the treatment of cancer

✍ Scribed by Dymock, Brian W; Drysdale, Martin J; McDonald, Edward; Workman, Paul


Book ID
120404724
Publisher
Informa plc
Year
2004
Tongue
English
Weight
172 KB
Volume
14
Category
Article
ISSN
1354-3776

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## Abstract Activation of the Hsp90 chaperone system is a characteristic of cancer cells. The regulation of chaperone activities involves their interaction with cochaperones; therefore we investigated the expression of Hsp70 and Hsp90 and their specific co-chaperones HOP and CHIP in cancer cell lin